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Proceedings of the National Academy of Sciences current issuehttp://www.pnas.orgProceedings of the National Academy of Sciences RSS feed -- current issue1091-6490Dec 2 2008 12:00:00:000AMProceedings of the National Academy of Sciences0027-8424 Proceedings of the National Academy of Scienceshttp://www.pnas.org/icons/banner/title.gifhttp://www.pnas.orghttp://www.pnas.org/cgi/content/short/105/48/E95?rss=12008-12-02info:doi/10.1073/pnas.0809328105National Academy of Sciences of the USA48105E952008-12-02E95Lettershttp://www.pnas.org/cgi/content/short/105/48/E96?rss=12008-12-02info:doi/10.1073/pnas.0810008105National Academy of Sciences of the USA48105E962008-12-02E96Lettershttp://www.pnas.org/cgi/content/short/105/48/E97?rss=12008-12-02info:doi/10.1073/pnas.0808990105National Academy of Sciences of the USA48105E972008-12-02E97Lettershttp://www.pnas.org/cgi/content/short/105/48/E98?rss=12008-12-02info:doi/10.1073/pnas.0810299105National Academy of Sciences of the USA48105E982008-12-02E98Lettershttp://www.pnas.org/cgi/content/short/105/48/E99?rss=12008-12-02info:doi/10.1073/pnas.0807625105National Academy of Sciences of the USA48105E992008-12-02E99Lettershttp://www.pnas.org/cgi/content/short/105/48/E100?rss=12008-12-02info:doi/10.1073/pnas.0809681105National Academy of Sciences of the USA48105E1002008-12-02E100Lettershttp://www.pnas.org/cgi/content/short/105/48/18645?rss=12008-12-02info:doi/10.1073/iti4808105National Academy of Sciences of the USA48105186462008-12-0218645This Week in PNAShttp://www.pnas.org/cgi/content/short/105/48/18647?rss=12008-12-02info:doi/10.1073/pnas.0810508106National Academy of Sciences of the USA48105186482008-12-0218647Commentaryhttp://www.pnas.org/cgi/content/short/105/48/18649?rss=12008-12-02info:doi/10.1073/pnas.0810568106National Academy of Sciences of the USA48105186502008-12-0218649Commentaryhttp://www.pnas.org/cgi/content/short/105/48/18651?rss=12008-12-02info:doi/10.1073/pnas.0810158106National Academy of Sciences of the USA48105186522008-12-0218651Commentaryhttp://www.pnas.org/cgi/content/short/105/48/18653?rss=12008-12-02info:doi/10.1073/pnas.0810505106National Academy of Sciences of the USA48105186542008-12-0218653Commentaryhttp://www.pnas.org/cgi/content/short/105/48/18655?rss=1An extensive set of equilibrium and kinetic data is presented and analyzed for an ultrafast folding protein—the villin subdomain. The...]]>2008-12-02info:doi/10.1073/pnas.0808600105National Academy of Sciences of the USA48105186622008-12-0218655Biophysicshttp://www.pnas.org/cgi/content/short/105/48/18663?rss=1Familial amyotrophic lateral sclerosis (fALS) caused by mutations in copper–zinc superoxide diase (SOD1) is characterized by the presence of SOD1-rich...]]>2008-12-02info:doi/10.1073/pnas.0807058105National Academy of Sciences of the USA48105186682008-12-0218663Biophysicshttp://www.pnas.org/cgi/content/short/105/48/18669?rss=1The vertebrate inner ear possesses an active process that provides nonlinear amplification of mechanical stimuli. A candidate for this process...]]>2008-12-02info:doi/10.1073/pnas.0805752105National Academy of Sciences of the USA48105186742008-12-0218669Biophysicshttp://www.pnas.org/cgi/content/short/105/48/18675?rss=1Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable...]]>2008-12-02info:doi/10.1073/pnas.0807476105National Academy of Sciences of the USA48105186802008-12-0218675Applied_Physical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18681?rss=1The computational cost of exact methods for quantum simulation using classical computers grows exponentially with system size. As a consequence,...]]>2008-12-02info:doi/10.1073/pnas.0808245105National Academy of Sciences of the USA48105186862008-12-0218681Chemistryhttp://www.pnas.org/cgi/content/short/105/48/18687?rss=1The condensation, evaporation, and repartitioning of semivolatile organic compounds (SVOCs) in the atmosphere depends both on the phase of condensed...]]>2008-12-02info:doi/10.1073/pnas.0802144105National Academy of Sciences of the USA48105186912008-12-0218687Environmental_Sciences-PShttp://www.pnas.org/cgi/content/short/105/48/18692?rss=1Tidal deltas are characterized by a dendritic network of distributaries that transport water and sediments to the ocean. Here, I...]]>2008-12-02info:doi/10.1073/pnas.0806668105National Academy of Sciences of the USA48105186952008-12-0218692Geologyhttp://www.pnas.org/cgi/content/short/105/48/18696?rss=1A classical set of birational invariants of a variety are its spaces of pluricanonical forms and some of their canonically...]]>2008-12-02info:doi/10.1073/pnas.0809030105National Academy of Sciences of the USA48105187012008-12-0218696Mathematicshttp://www.pnas.org/cgi/content/short/105/48/18702?rss=1An important issue in the study of cities is defining a metropolitan area, because different definitions affect conclusions regarding the...]]>2008-12-02info:doi/10.1073/pnas.0807435105National Academy of Sciences of the USA48105187072008-12-0218702Physicshttp://www.pnas.org/cgi/content/short/105/48/18708?rss=1Silver(I) hexacyanocobaltate(III), Ag3[Co(CN)6], shows a large negative linear compressibility (NLC, linear expansion under hydrostatic pressure) at ambient temperature at all...]]>2008-12-02info:doi/10.1073/pnas.0804789105National Academy of Sciences of the USA48105187132008-12-0218708Physicshttp://www.pnas.org/cgi/content/short/105/48/18714?rss=1In ecology, there have been attempts to establish links between the relative species abundance (RSA), the fraction of species in...]]>2008-12-02info:doi/10.1073/pnas.0807380105National Academy of Sciences of the USA48105187172008-12-0218714Physicshttp://www.pnas.org/cgi/content/short/105/48/18718?rss=1We develop a general framework for performing large-scale significance testing in the presence of arbitrarily strong dependence. We derive a...]]>2008-12-02info:doi/10.1073/pnas.0808709105National Academy of Sciences of the USA48105187232008-12-0218718Statisticshttp://www.pnas.org/cgi/content/short/105/48/18724?rss=1Heparan sulfate (HS) is a polysaccharide involved in essential physiological functions from regulating cell growth to blood coagulation. HS biosynthesis...]]>2008-12-02info:doi/10.1073/pnas.0806975105National Academy of Sciences of the USA48105187292008-12-0218724Biochemistryhttp://www.pnas.org/cgi/content/short/105/48/18730?rss=1The Saccharomyces cerevisiae Mec1–Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an essential regulator of genomic integrity. The...]]>2008-12-02info:doi/10.1073/pnas.0806621105National Academy of Sciences of the USA48105187342008-12-0218730Biochemistryhttp://www.pnas.org/cgi/content/short/105/48/18735?rss=1We have restored the CoQ oxidative capacity of mouse mtDNA-less cells (° cells) by transforming them with the alternative oxidase...]]>2008-12-02info:doi/10.1073/pnas.0810518105National Academy of Sciences of the USA48105187392008-12-0218735Biochemistryhttp://www.pnas.org/cgi/content/short/105/48/18740?rss=1One of the most striking topological features to be found in a protein is that of a distinct knot formed...]]>2008-12-02info:doi/10.1073/pnas.0806697105National Academy of Sciences of the USA48105187452008-12-0218740Biophysicshttp://www.pnas.org/cgi/content/short/105/48/18746?rss=1Regulation of mitochondrial outer membrane (MOM) permeability has dual importance: in normal metabolite and energy exchange between mitochondria and cytoplasm...]]>2008-12-02info:doi/10.1073/pnas.0806303105National Academy of Sciences of the USA48105187512008-12-0218746Biophysicshttp://www.pnas.org/cgi/content/short/105/48/18752?rss=1An explicit proposal for experiments leading to abrupt transitions in spatially extended bacterial populations in a Petri dish is presented...]]>2008-12-02info:doi/10.1073/pnas.0805215105National Academy of Sciences of the USA48105187572008-12-0218752Biophysicshttp://www.pnas.org/cgi/content/short/105/48/18758?rss=1Transforming growth factor-β (TGF-β) activity is controlled at many levels including the conversion of the latent secreted form to its...]]>2008-12-02info:doi/10.1073/pnas.0805411105National Academy of Sciences of the USA48105187632008-12-0218758Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18764?rss=1Cytokinesis in unicellular organisms sometimes entails a division of labor between cells leading to lineage-specific aging. To investigate the potential...]]>2008-12-02info:doi/10.1073/pnas.0804550105National Academy of Sciences of the USA48105187692008-12-0218764Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18770?rss=1Extracellular ATP controls various signaling systems including propagation of intercellular Ca2+ signals (ICS). Connexin hemichannels, P2x7 receptors (P2x7Rs), pannexin channels,...]]>2008-12-02info:doi/10.1073/pnas.0800793105National Academy of Sciences of the USA48105187752008-12-0218770Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18776?rss=1Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within...]]>2008-12-02info:doi/10.1073/pnas.0800831105National Academy of Sciences of the USA48105187812008-12-0218776Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18782?rss=1Mammalian cells fuel their growth and proliferation through the catabolism of two main substrates: glucose and glutamine. Most of the...]]>2008-12-02info:doi/10.1073/pnas.0810199105National Academy of Sciences of the USA48105187872008-12-0218782Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18788?rss=1Brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 activates human ADP-ribosylation factor (ARF) 1 and 3 by accelerating the replacement of...]]>2008-12-02info:doi/10.1073/pnas.0810104105National Academy of Sciences of the USA48105187932008-12-0218788Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18794?rss=1The transcription factor c-Myc is essential for cellular proliferation and is one of the most frequently activated oncogenes, but the...]]>2008-12-02info:doi/10.1073/pnas.0806879105National Academy of Sciences of the USA48105187992008-12-0218794Cell_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18800?rss=1Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP)....]]>2008-12-02info:doi/10.1073/pnas.0808868105National Academy of Sciences of the USA48105188052008-12-0218800Developmental_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18806?rss=1Articulated jaws are highly conserved structures characteristic of gnathostome evolution. Epithelial-mesenchymal interactions within the first pharyngeal arch (PA1) instruct cephalic...]]>2008-12-02info:doi/10.1073/pnas.0807345105National Academy of Sciences of the USA48105188112008-12-0218806Developmental_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18812?rss=1Wnt proteins regulate the formation of central synapses by stimulating synaptic assembly, but their role at the vertebrate neuromuscular junction...]]>2008-12-02info:doi/10.1073/pnas.0806300105National Academy of Sciences of the USA48105188172008-12-0218812Developmental_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18818?rss=1Lateral roots are initiated postembryonically in response to environmental cues, enabling plants to explore efficiently their underground environment. However, the...]]>2008-12-02info:doi/10.1073/pnas.0807814105National Academy of Sciences of the USA48105188232008-12-0218818Developmental_Biologyhttp://www.pnas.org/cgi/content/short/105/48/18824?rss=1The identification of key populations shaping the structure and connectivity of metapopulation systems is a major challenge in population ecology....]]>2008-12-02info:doi/10.1073/pnas.0805571105National Academy of Sciences of the USA48105188292008-12-0218824Ecologyhttp://www.pnas.org/cgi/content/short/105/48/18830?rss=1Environmental noise that reduces the probability that animals will detect communicative signals poses a special challenge for long-range communication. The...]]>2008-12-02info:doi/10.1073/pnas.0807657105National Academy of Sciences of the USA48105188352008-12-0218830Ecologyhttp://www.pnas.org/cgi/content/short/105/48/18836?rss=1Chance events such as seed dispersal determine the potential composition of plant communities, but the eventual assemblage is determined in...]]>2008-12-02info:doi/10.1073/pnas.0807216105National Academy of Sciences of the USA48105188412008-12-0218836Ecologyhttp://www.pnas.org/cgi/content/short/105/48/18842?rss=1Mounting concern over the loss of marine biodiversity has increased the urgency of understanding its consequences. This urgency spurred the...]]>2008-12-02info:doi/10.1073/pnas.0806425105National Academy of Sciences of the USA48105188472008-12-0218842Ecologyhttp://www.pnas.org/cgi/content/short/105/48/18848?rss=1Increasing global concentrations of atmospheric CO2 are predicted to decrease ocean pH, with potentially severe impacts on marine food webs,...]]>2008-12-02info:doi/10.1073/pnas.0810079105National Academy of Sciences of the USA48105188532008-12-0218848Environmental_Sciences-BShttp://www.pnas.org/cgi/content/short/105/48/18854?rss=1Biological ice nucleators (IN) function as catalysts for freezing at relatively warm temperatures (warmer than –10 °C). We examined the...]]>2008-12-02info:doi/10.1073/pnas.0809816105National Academy of Sciences of the USA48105188592008-12-0218854Environmental_Sciences-BShttp://www.pnas.org/cgi/content/short/105/48/18860?rss=1Southern Ocean acidification via anthropogenic CO2 uptake is expected to be detrimental to multiple calcifying plankton species by lowering the...]]>2008-12-02info:doi/10.1073/pnas.0806318105National Academy of Sciences of the USA48105188642008-12-0218860Environmental_Sciences-BShttp://www.pnas.org/cgi/content/short/105/48/18865?rss=1The cystic fibrosis transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily, an ancient family...]]>2008-12-02info:doi/10.1073/pnas.0806306105National Academy of Sciences of the USA48105188702008-12-0218865Evolutionhttp://www.pnas.org/cgi/content/short/105/48/18871?rss=1Sterility is common in hybrids between divergent populations, such as the indica and japonica subspecies of Asian cultivated rice (Oryza...]]>2008-12-02info:doi/10.1073/pnas.0810108105National Academy of Sciences of the USA48105188762008-12-0218871Geneticshttp://www.pnas.org/cgi/content/short/105/48/18877?rss=18-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts...]]>2008-12-02info:doi/10.1073/pnas.0806464105National Academy of Sciences of the USA48105188822008-12-0218877Geneticshttp://www.pnas.org/cgi/content/short/105/48/18883?rss=1Delayed allograft function (DGF) is a common adverse event in postrenal transplantation. The etiology of DGF is thought to include...]]>2008-12-02info:doi/10.1073/pnas.0810308105National Academy of Sciences of the USA48105188882008-12-0218883Immunologyhttp://www.pnas.org/cgi/content/short/105/48/18889?rss=1Multiple sclerosis (MS) is a chronic relapsing disease of the central nervous system (CNS) in which immune processes are believed...]]>2008-12-02info:doi/10.1073/pnas.0806310105National Academy of Sciences of the USA48105188942008-12-0218889Immunologyhttp://www.pnas.org/cgi/content/short/105/48/18895?rss=1The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this...]]>2008-12-02info:doi/10.1073/pnas.0810246105National Academy of Sciences of the USA48105189002008-12-0218895Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18901?rss=1During inflammation, a large amount of arachidonic acid (AA) is released into the cellular milieu and cyclooxygenase enzymes convert this...]]>2008-12-02info:doi/10.1073/pnas.0809765105National Academy of Sciences of the USA48105189062008-12-0218901Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18907?rss=1Efforts to model pancreatic cancer in mice have focused on mimicking genetic changes found in the human disease, particularly the...]]>2008-12-02info:doi/10.1073/pnas.0810111105National Academy of Sciences of the USA48105189122008-12-0218907Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18913?rss=1Pancreatic ductal adenocarcinoma (PDAC) is believed to arise through a multistep model comprised of putative precursor lesions known as pancreatic...]]>2008-12-02info:doi/10.1073/pnas.0810097105National Academy of Sciences of the USA48105189182008-12-0218913Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18919?rss=1Dysregulated Wnt signaling is seen in approximately 30% of hepatocellular carcinomas; thus, finding pathways downstream of the activation of Wnt...]]>2008-12-02info:doi/10.1073/pnas.0805778105National Academy of Sciences of the USA48105189232008-12-0218919Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18924?rss=1Nitric oxide (NO) is involved in number of physiological and pathological events. Our previous studies demonstrated a differential expression of...]]>2008-12-02info:doi/10.1073/pnas.0810230105National Academy of Sciences of the USA48105189292008-12-0218924Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18930?rss=1Noonan syndrome (NS) is the most common nonchromosomal genetic disorder associated with cardiovascular malformations. The most prominent cardiac defects in...]]>2008-12-02info:doi/10.1073/pnas.0806556105National Academy of Sciences of the USA48105189352008-12-0218930Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18936?rss=1Patients with cancer have circulating heterophile antibodies that agglutinate animal red cells via recognition of the mammalian cell surface sialic...]]>2008-12-02info:doi/10.1073/pnas.0803943105National Academy of Sciences of the USA48105189412008-12-0218936Medical_Scienceshttp://www.pnas.org/cgi/content/short/105/48/18942?rss=1In contrast to the cell division machineries of bacteria, euryarchaea, and eukaryotes, no division components have been identified in the...]]>2008-12-02info:doi/10.1073/pnas.0809467105National Academy of Sciences of the USA48105189462008-12-0218942Microbiologyhttp://www.pnas.org/cgi/content/short/105/48/18947?rss=1The histone-like nucleoid structuring protein, H-NS, is a prominent global regulator of gene expression. Many Gram-negative bacteria contain multiple members...]]>2008-12-02info:doi/10.1073/pnas.0808215105National Academy of Sciences of the USA48105189522008-12-0218947Microbiologyhttp://www.pnas.org/cgi/content/short/105/48/18953?rss=1The stress-bearing component of the bacterial cell wall—a multi-gigadalton bag-like molecule called the sacculus—is synthesized from peptidoglycan. Whereas the chemical...]]>2008-12-02info:doi/10.1073/pnas.0808035105National Academy of Sciences of the USA48105189572008-12-0218953Microbiologyhttp://www.pnas.org/cgi/content/short/105/48/18958?rss=1The nitrogen-fixing symbiosis between rhizobia and legume plants is a model of coevolved nutritional complementation. The plants reduce atmospheric CO2...]]>2008-12-02info:doi/10.1073/pnas.0808048105National Academy of Sciences of the USA48105189632008-12-0218958Microbiologyhttp://www.pnas.org/cgi/content/short/105/48/18964?rss=1Following birth, the breast-fed infant gastrointestinal tract is rapidly colonized by a microbial consortium often dominated by bifidobacteria. Accordingly, the...]]>2008-12-02info:doi/10.1073/pnas.0809584105National Academy of Sciences of the USA48105189692008-12-0218964Microbiologyhttp://www.pnas.org/cgi/content/short/105/48/18970?rss=1To perform nontrivial, real-time computations on a sensory input stream, biological systems must retain a short-term memory trace of their...]]>2008-12-02info:doi/10.1073/pnas.0804451105National Academy of Sciences of the USA48105189752008-12-0218970Neurosciencehttp://www.pnas.org/cgi/content/short/105/48/18976?rss=1Mood disorders cause much suffering and are the single greatest cause of lost productivity worldwide. Although multiple medications, along with...]]>2008-12-02info:doi/10.1073/pnas.0800466105National Academy of Sciences of the USA48105189812008-12-0218976Neurosciencehttp://www.pnas.org/cgi/content/short/105/48/18982?rss=1Time lapse fluorescence imaging has become one of the most important approaches in neurobiological research. In particular, both confocal and...]]>2008-12-02info:doi/10.1073/pnas.0810028105National Academy of Sciences of the USA48105189872008-12-0218982Neurosciencehttp://www.pnas.org/cgi/content/short/105/48/18988?rss=1Competition among different axons to reach the somatodendritic region of the target neuron is an important event during development to...]]>2008-12-02info:doi/10.1073/pnas.0806979105National Academy of Sciences of the USA48105189932008-12-0218988Neurosciencehttp://www.pnas.org/cgi/content/short/105/48/18994?rss=1Because the excitable properties of neurons in the neocortex depend on the characteristics of voltage-gated Na+ channels, factors which regulate...]]>2008-12-02info:doi/10.1073/pnas.0803464105National Academy of Sciences of the USA48105189992008-12-0218994Neurosciencehttp://www.pnas.org/cgi/content/short/105/48/19000?rss=1In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy-retinal) is essential for photoreceptor cell...]]>2008-12-02info:doi/10.1073/pnas.0807805105National Academy of Sciences of the USA48105190052008-12-0219000Neurosciencehttp://www.pnas.org/cgi/content/short/105/48/19006?rss=1Despite the use of the sirolimus (rapamycin) drug-eluting coronary stent, diabetics are at increased risk of developing in-stent restenosis for...]]>2008-12-02info:doi/10.1073/pnas.0809743105National Academy of Sciences of the USA48105190112008-12-0219006Pharmacologyhttp://www.pnas.org/cgi/content/short/105/48/19012?rss=1Estrogen receptor (ER) dimerization is prerequisite for its activation of target gene transcription. Because the two forms of ER, ER...]]>2008-12-02info:doi/10.1073/pnas.0807274105National Academy of Sciences of the USA48105190172008-12-0219012Pharmacologyhttp://www.pnas.org/cgi/content/short/105/48/19018?rss=1Human papillomavirus (HPV) vaccines provide an opportunity to reduce the incidence of cervical cancer. Optimization of cervical cancer prevention programs...]]>2008-12-02info:doi/10.1073/pnas.0808114105National Academy of Sciences of the USA48105190232008-12-0219018Population_Biologyhttp://www.pnas.org/cgi/content/short/105/48/19024?rss=12008-12-02info:doi/10.1073/pnas.0810309105National Academy of Sciences of the USA48105190242008-12-0219024erratahttp://www.pnas.org/cgi/content/short/105/48/19024-a?rss=12008-12-02info:doi/10.1073/pnas.0809025105National Academy of Sciences of the USA48105190242008-12-0219024errata
 

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